About 3 weeks ago, the media told you that Biden was “sharp as a tack” 🙄

2 days ago, the poor guy was basically forced at gunpoint to resign as Dem nominee. His staff weren’t even informed.

Now they say Kamala is the best thing ever 🤦‍♂️ pic.twitter.com/E58MlrQZqI

— Elon Musk (@elonmusk) July 24, 2024

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Stop It!!! She’s Here To Save Democracy! | Il Donaldo Trumpo | X | Video: 9 Seconds

By Great Bloggers | July 23, 2024

STOP IT!!!🤣🤣🤣 SHE’S HERE TO “SAVE DEMOCRACY”!!! pic.twitter.com/ImcXoiBZQw

— il Donaldo Trumpo (@PapiTrumpo) July 23, 2024

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Dominion Voting Machines Are Connected To The Internet | X

By Great Bloggers | July 22, 2024

BREAKING: Reports are coming from Maricopa County, Arizona that Dominion voting machines are malfunctioning county-wide as a result of the CrowdStrike outage. Officials have long claimed that the machines are NEVER connected to the internet… you can laugh at those claims now… pic.twitter.com/t5A6SIImKY

— George (@BehizyTweets) July 19, 2024

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Now that the FBI is charge of the investigation, we’ll never know the truth. | X

By Great Bloggers | July 18, 2024

Now that the FBI is charge of the investigation, we’ll never know the truth. pic.twitter.com/LK4MzxnDxI

— Paul Hookem 🇺🇸 (@PaulHook_em) July 18, 2024

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Seems Normal | Secret Service Lookout | X

By Great Bloggers | July 18, 2024

STOP IT!!!😂😂😂 pic.twitter.com/ncPwXuQonU

— il Donaldo Trumpo (@PapiTrumpo) July 17, 2024

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Pure Evil | Jack Prosobiec | X

By Great Bloggers | July 18, 2024

Pure evil pic.twitter.com/YDIN4kWU6o

— Jack Poso 🇺🇸 (@JackPosobiec) July 17, 2024

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The Greatest Donald Trump Impersonator Is Voting For The ‘Outlaw’ President | Video: 1 Minutes 10 Seconds

By Great Bloggers | May 31, 2024

The world’s greatest Trump impersonator, Shawn Farash.

Shawn is voting for the Outlaw President.pic.twitter.com/SiC52qlqJ0

— Citizen Free Press (@CitizenFreePres) May 31, 2024

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It’s All An Effort To “Get” Donald Trump | Governor Ron DeSantis

By Great Bloggers | May 31, 2024

Today’s verdict represents the culmination of a legal process that has been bent to the political will of the actors involved: a leftist prosecutor, a partisan judge and a jury reflective of one of the most liberal enclaves in America—all in an effort to “get” Donald Trump.

That…

— Ron DeSantis (@GovRonDeSantis) May 30, 2024

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Do You Still Believe The Legacy Media? | Video: 1 Minute 43 Seconds

By Great Bloggers | May 23, 2024

Some people still believe the legacy media https://t.co/AZUnqJNibP

— Elon Musk (@elonmusk) May 23, 2024

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Vaccine Injuries Censorship | Chris Cuomo | Video: 5 Minutes 55 Seconds

By Great Bloggers | May 9, 2024

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RFK, Jr. | Video: 30 Minutes 23 Seconds

By Great Bloggers | May 8, 2024

The Bobby Kennedy video Meta doesn’t want you to see, narrated by Woody Harrelson. pic.twitter.com/oBieuglEYv

— Robert F. Kennedy Jr (@RobertKennedyJr) May 4, 2024

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Humanity On Mars | Elon Musk | Video: 44 Minutes 20 Seconds

By Great Bloggers | April 7, 2024

At Starbase, @ElonMusk provided an update on the company’s plans to send humanity to Mars, the best destination to begin making life multiplanetary pic.twitter.com/PiX8XOgQs5

— SpaceX (@SpaceX) April 6, 2024

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Therapy Disparaged For Use With Covid-19 Produces 100% Remission In Advanced Colon Cancer | You Use Your Own Innate Immunity To Heal Yourself | Video: 7 Minutes 50 Seconds

By Great Bloggers | April 3, 2024

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PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer | The NEW ENGLAND JOURNAL Of MEDICINE

By Great Bloggers | April 3, 2024

Authors: Andrea Cercek, M.D., Melissa Lumish, M.D. https://orcid.org/0000-0003-4173-5567, Jenna Sinopoli, N.P., Jill Weiss, B.A., Jinru Shia, M.D., MichelleLamendola-Essel, D.H.Sc., Imane H. El Dika, M.D., and Luis A. Diaz, Jr., M.D.

BACKGROUND

Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is caused by a deficiency in mismatch repair. Because mismatch repair–deficient colorectal cancer is responsive to programmed death 1 (PD-1) blockade in the context of metastatic disease, it was hypothesized that checkpoint blockade could be effective in patients with mismatch repair–deficient, locally advanced rectal cancer.

METHODS

We initiated a prospective phase 2 study in which single-agent dostarlimab, an anti–PD-1 monoclonal antibody, was administered every 3 weeks for 6 months in patients with mismatch repair–deficient stage II or III rectal adenocarcinoma. This treatment was to be followed by standard chemoradiotherapy and surgery. Patients who had a clinical complete response after completion of dostarlimab therapy would proceed without chemoradiotherapy and surgery. The primary end points are sustained clinical complete response 12 months after completion of dostarlimab therapy or pathological complete response after completion of dostarlimab therapy with or without chemoradiotherapy and overall response to neoadjuvant dostarlimab therapy with or without chemoradiotherapy.

PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

RESULTS

A total of 12 patients have completed treatment with dostarlimab and have undergone at least 6 months of follow-up. All 12 patients (100%; 95% confidence interval, 74 to 100) had a clinical complete response, with no evidence of tumor on magnetic resonance imaging, ¹⁸F-fluorodeoxyglucose–positron-emission tomography, endoscopic evaluation, digital rectal examination, or biopsy. At the time of this report, no patients had received chemoradiotherapy or undergone surgery, and no cases of progression or recurrence had been reported during follow-up (range, 6 to 25 months). No adverse events of grade 3 or higher have been reported.

CONCLUSIONS

Mismatch repair–deficient, locally advanced rectal cancer was highly sensitive to single-agent PD-1 blockade. Longer follow-up is needed to assess the duration of response. (Funded by the Simon and Eve Colin Foundation and others; ClinicalTrials.gov number, NCT04165772.)

Locally advanced rectal cancer is typically managed with multimodal therapy, including chemotherapy, radiation, and surgery. Current evidence supports a strategy involving the use of neoadjuvant therapy, in which induction chemotherapy with a fluoropyrimidine in combination with oxaliplatin is followed by chemoradiotherapy and then surgery.^1-3 This approach results in a pathological complete response in up to a quarter of patients, but it is associated with marked complications and toxic effects — including bowel, urinary, and sexual dysfunction; infertility; and altered quality of life — in a substantial proportion of patients.^4-6 In patients undergoing surgery, resection of the rectum is life-altering and often warrants a permanent diverting colostomy.^6,7 Owing to the complications of surgery and the high frequency of pathological complete response, interest in organ-sparing nonoperative management is increasing. The use of clinical complete response that is achieved with neoadjuvant treatment as a surrogate for pathological complete response provides patients with a nonoperative option that results in a survival benefit that is similar to that in patients undergoing surgical resection.^8-11

Approximately 5 to 10% of rectal adenocarcinomas are mismatch-repair deficient, and these tumors have been shown to respond poorly to standard chemotherapy regimens, including neoadjuvant chemotherapy in locally advanced rectal cancer.^12-14 Immune checkpoint blockade alone has been shown to be highly effective as first-line treatment for patients with mismatch repair–deficient metastatic colorectal cancer, as well as for patients with treatment-refractory disease, with objective response rates of 33 to 55%, clinically significant durability of response, and prolonged overall survival.^15-17

On the basis of the benefits seen in the context of metastatic disease, we hypothesized that single-agent programmed death 1 (PD-1) blockade alone might be beneficial in mismatch repair–deficient, locally advanced rectal cancer. To test this hypothesis, we initiated a phase 2 study to investigate the overall response and frequency of sustained clinical complete response to neoadjuvant treatment with dostarlimab, a PD-1 inhibitor, in this patient population.

Full Article |PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer | The New England Journal of Medicine

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100 Percent Cancer Remission of Patients in Monoclonal Antibody Trial | Facts Matter | Epoch Times

By Great Bloggers | April 3, 2024

According to the results of a recent study, researchers have found a treatment that completely removed the rectal cancer in every patient that participated. Meaning that every single patient in the study is in remission—and with no chemotherapy, no radiation, and no surgery.

Even though the study was small, the results are not only heartening, but also, according to the lead researcher, they open up a potential new corridor at fighting cancer, which they will be expanding quickly to stomach, pancreatic, and bladder cancer.

Furthermore, the therapy that they’re testing (monoclonal antibodies) has none of the toxic side-effects of the other treatments for cancer that are currently used at scale.

And so, with all these positive elements lining up, let’s go through this study together.

Episode Resources:

🔵 Full Study:

https://ept.ms/3J1Iffx

🌽No Farmers No Food DVD:

https://www.epochtv.shop/product-page/no-farmers-no-food-documentary-dvd

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Real Love!! | Il Donaldo Trumpo | Video: 45 Seconds

By Great Bloggers | March 16, 2024

REAL LOVE!!!❤️🇺🇸 pic.twitter.com/kPI5Ptzy4o

— il Donaldo Trumpo (@PapiTrumpo) March 15, 2024

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This Is Why Elon Is Suing OpenAI | Video: 54 Seconds

By Great Bloggers | March 5, 2024

This is why Elon is suing OpenAI pic.twitter.com/Py8UOlLq43

— Teslaconomics (@Teslaconomics) March 2, 2024

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The Pinocchio . . . Biden Administration On The Open Border | Video: 15 Seconds

By Great Bloggers | March 4, 2024

WHO DID THIS???😂😂😂 pic.twitter.com/zDZEpKnVcC

— il Donaldo Trumpo (@PapiTrumpo) March 3, 2024

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Federal Health Agencies and the COVID Cartel: What Are They Hiding | United States Senate Hearing | Video: 14 Minutes 15 Seconds

By Great Bloggers | March 1, 2024

For those who can’t spend 4 hours watching the full roundtable event – Federal Health Agencies and the COVID Cartel: What Are They Hiding – here is a 14-minute edited version that captures many important points. pic.twitter.com/YLpYaLp5gT

— Senator Ron Johnson (@SenRonJohnson) February 29, 2024

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How To End The War In Ukraine | Video: 25 Seconds

By Great Bloggers | February 28, 2024

IN 24 HOURS I’LL GET IT DONE!!!😂😂😂 pic.twitter.com/Z82jAkZPcP

— il Donaldo Trumpo (@PapiTrumpo) February 26, 2024

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The War On Children | Posted By Elon Musk, “Worth Watching”

By Great Bloggers | February 19, 2024

Worth watching, especially for parents pic.twitter.com/k6gb2CMVqU

— Elon Musk (@elonmusk) February 18, 2024

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Robert F Kennedy, Jr. | Video: 1 Minute 27 Seconds

By Great Bloggers | December 28, 2023

.@joerogan + @TuckerCarlson + @patrickbetdavid + @PiersUncensored + @jack + @ChrisCuomo + @TimJDillon share their thoughts on my campaign. #Kennedy24 pic.twitter.com/4XKRHILrFa

— Robert F. Kennedy Jr (@RobertKennedyJr) December 26, 2023

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Ga. Secretary of State Refusing To Testify In Dominion Voting Machine Case | Phil Kent | James Magazine Online

By Great Bloggers | December 28, 2023

Last month U.S. District Judge Amy Totenberg ruled that a lawsuit against Georgia’s use of electronic voting machines must go to a non-jury trial in January. She ordered Secretary of State Brad Raffensperger to defend the state’s utilization of electronic voting prior to the upcoming presidential primary election because the lawsuit questions whether Georgia’s current system of computerized voting is safe or whether it is vulnerable to potential hacking.
However, the state (spending taxpayer money) is now appealing to the 11th Circuit Court of Appeals to keep Raffensperger from testifying.
Says one lawyer to James Magazine Online familiar with the case: “Raffensperger selected the system, repeatedly defends the system as secure, but now can’t take an hour or so in federal court to defend it.”

Ga. Secretary of State Refusing To Testify | Phil Kent | James Magazine Online

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Julian Assange Should Be Freed | Tucker Carlson | Video: 5 Minutes 44 Seconds

By Great Bloggers | December 23, 2023

TC Shorts: Julian Assange pic.twitter.com/usckyGH9B2

— Tucker Carlson (@TuckerCarlson) December 22, 2023

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Just Because Rattling The Obscene Is A Moral Obligation | The Alex Jones Interview | Tucker Carlson | Video: 1 Hour 31 Minutes 50 Seconds

By Great Bloggers | December 8, 2023

Ep. 46 The Alex Jones Interview

TIMESTAMPS:

2:46 Alex Jones predictions
15:07 Deplatforming
21:59 Dividing us on race
25:37 The border
28:09 Austin
32:12 New World Order
42:09 Brian Stelter demon video
50:57 Depopulation
1:07:51 Food
1:13:51 Whiskey
1:16:22 Presidential… pic.twitter.com/IsJAQDUzDc

— Tucker Carlson (@TuckerCarlson) December 7, 2023

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Democrats, The Party Of The Ku Klux Klan, Show Their True Feathers | The Genocide Of All Jews | Video: 3 Minutes 28 Seconds

By Great Bloggers | December 6, 2023

The presidents of @Harvard, @MIT, and @Penn were all asked the following question under oath at today’s congressional hearing on antisemitism:

Does calling for the genocide of Jews violate [your university’s] code of conduct or rules regarding bullying or harassment?

The… pic.twitter.com/eVlPCHMcVZ

— Bill Ackman (@BillAckman) December 5, 2023

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Blackmail Should Never Be A Good Business Practice | Elon Musk | Video: 23 Seconds

By Great Bloggers | November 30, 2023

Okay, now this is hilarious 😂 pic.twitter.com/foY6zQ4NYY

— Teslaconomics (@Teslaconomics) November 30, 2023

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The Party Of The Ku Klux Klan Never Changes | If You Don’t Think The Democrat Establishment Is More Than Happy To Allow Your Family To Be Robbed, Raped, & Even Murdered, Think Again | Vince Ricci Video: 1 Minute 53 Seconds

By Great Bloggers | November 19, 2023

Vince Ricci was coming back to his LA home on a quiet evening when two robbers jumped his wall and pointed guns at his chest.

But they weren’t ready for what was about to happen. He had a gun of his own and defended himself.

Now, California is suspending his Second Amendment. pic.twitter.com/sF0O76eO1M

— NRA (@NRA) November 17, 2023

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Democrats Have Always Projected Their Racism Onto The Rest Of Us | “You Smelly Nigga” ~ Howard Stern | Video: 1 Minute 23 Seconds

By Great Bloggers | November 10, 2023

Here is the perfect modern example of why so many of us have left the Democrat Party. It is the party of the Ku Klux Klan, the party of Jim Crow Laws, the party of Tammany Hall, seditious infiltration of a corrupt FBI, race baiting, and Trump Derangement Syndrome.

Here is a rare clip of Howard Stern in Black Face using the term ‘smelly nigga’ in 1993. pic.twitter.com/2dEzwhkb4J

— Dom Lucre | Breaker of Narratives (@dom_lucre) November 10, 2023

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“The 2020 Election Was Rigged” | Vivek Ramaswamy | Video: 1 Minute 44 Seconds

By Great Bloggers | November 9, 2023

Wow…
Vivek Ramaswamy just went absolute savage mode on the RNC, calling out Ronna by name, and then NBC, flipping the moderator question back onto the moderator. Has this ever been done? pic.twitter.com/Hmdo7o5oY5

— Charlie Kirk (@charliekirk11) November 9, 2023

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Donald Trump Trial Is A Kangaroo Court | Video: 2 Minutes 13 Seconds

By Great Bloggers | November 7, 2023

REPORT: Donald Trump reportedly pulled out a piece of paper from his suit jacket in court, claiming it would clear him of all wrongdoing in the $250M fraud case.

Left-wing Judge Arthur Engoron refused to let him read it.

The paper in question reportedly was a disclaimer clause… pic.twitter.com/iIAZkoFdBK

— Collin Rugg (@CollinRugg) November 7, 2023

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No Wonder The Mainstream Media Hates El Salvadoran President Nayib Bukele | Full Interview With Tucker Carlson | Video: 1 Hour 3 Seconds

By Great Bloggers | November 6, 2023

Might be a good time to watch this interview from a year ago with @TuckerCarlson… https://t.co/wDd5ygMKVM

— Nayib Bukele (@nayibbukele) October 25, 2023

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Elon Musk on Buying Twitter and Turning It Into X | Joe Rogan | Video: 13 Minutes 44 Seconds

By Great Bloggers | November 4, 2023

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Unfortunately, This Exchange Shows The Great Divide That Can Happen To Us Over Time | Video: 3 Minutes 39 Seconds

By Great Bloggers | November 1, 2023

Epic exchange between @benshapiro and an anti-Israel activist at Oxford University today. This “highly educated” student doesn’t know basic history pic.twitter.com/vbpfDnetgu

— Chaya Raichik (@ChayaRaichik10) October 31, 2023

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Not Surprising That ‘Conspiracy Theorists’ Are Usually Right | NIH Admits They Funded China Wuhan Labs Covid Gain Of Function | Rand Paul & John Stossel | Video: 5 Minutes 46 Seconds

By Great Bloggers | October 25, 2023

@RandPaul’s new book, “Deception: The Great Covid Cover-Up,” charges Anthony Fauci and others with funding dangerous research in China, and then covering it up. pic.twitter.com/1c6elBFCwP

— John Stossel (@JohnStossel) October 24, 2023

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PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer | The NEW ENGLAND JOURNAL Of MEDICINE

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

Skip The Scoop | Seek Understanding

BACKGROUND

METHODS

RESULTS

CONCLUSIONS