Role Of Ivermectin In The Prevention Of SARS-CoV-2 Infection Among Healthcare Workers In India: A Matched Case-Control Study | NIH

2021 Feb 16;16(2):e0247163. doi: 10.1371/journal.pone.0247163. eCollection 2021.

Researchers: Priyamadhaba Behera 1Binod Kumar Patro 1Arvind Kumar Singh 1Pradnya Dilip Chandanshive 1Ravikumar S R 1Somen Kumar Pradhan 1Siva Santosh Kumar Pentapati 1Gitanjali Batmanabane 2Prasanta Raghab Mohapatra 3Biswa Mohan Padhy 4Shakti Kumar Bal 3Sudipta Ranjan Singh 5Rashmi Ranjan Mohanty 6

Background: Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers.

Conclusion: Two-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.

[National Institutes of Health]

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