Role Of Ivermectin In The Prevention Of SARS-CoV-2 Infection Among Healthcare Workers In India: A Matched Case-Control Study | NIH

2021 Feb 16;16(2):e0247163. doi: 10.1371/journal.pone.0247163. eCollection 2021.

Researchers: Priyamadhaba Behera 1, Binod Kumar Patro 1, Arvind Kumar Singh 1, Pradnya Dilip Chandanshive 1, Ravikumar S R 1, Somen Kumar Pradhan 1, Siva Santosh Kumar Pentapati 1, Gitanjali Batmanabane 2, Prasanta Raghab Mohapatra 3, Biswa Mohan Padhy 4, Shakti Kumar Bal 3, Sudipta Ranjan Singh 5, Rashmi Ranjan Mohanty 6

Background: Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infection among healthcare workers.

Conclusion: Two-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.

[National Institutes of Health]

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