National Institutes of Health: “We therefore hypothesize that nose and mouth washing with hydrogen peroxide may enhance those local innate responses to viral infections and help protect against viral infections, including the current coronavirus pandemic.”

Published: National Institutes of Health, June 1, 2020

Researchers: Arturo Armone Caruso,a Antonio Del Prete,b and Antonio Ivan Lazzarinoc,

Title: Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic

Abstract: We reviewed the literature concerning the innate response from nasal and oral epithelial cells and their reaction to hydrogen peroxide (H2O2). . . .

Methods: We searched the databases EMBASE and PubMed for relevant papers using the following entry terms: (“hydrogen peroxide” OR H2O2) AND (virus OR viral infection OR innate response). We have not used any other constrains. After duplicates were removed, we identified 2119 papers. . . .

Results: Moreover, a hydrogen peroxide solution of a concentration as little as 0.5% efficiently inactivates coronaviruses (e.g. SARS, MERS) on inanimate surfaces within 1 min [22]. This may justify the use of hydrogen peroxide washes in infected people too: the solution may decrease the viral load of their respiratory droplets, hence help tackle the spread in the community. . .

Conclusions: There are no randomized controlled trials or clinical observational studies concerning the curative or preventive effect of hydrogen peroxide against viral infections. However, the literature from in-vitro immunological studies clearly points out that the application of hydrogen peroxide on the epithelial cells of nose, throat and mouth may well be extremely effective against viruses, including coronaviruses. We strongly encourage the rapid development of randomized controlled trials in both SARS-CoV-2 positive and negative subjects to study the effects that we have hypothesized.

Full Paper At The National Institutes of Health: “Hydrogen peroxide and viral infections: A literature review with research hypothesis definition in relation to the current covid-19 pandemic“.

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